Bioorganometallic fulvene-derived titanocene anti-cancer drugs.

Abstract

6-Substituted fulvenes are interesting and easily accessible starting materials for the synthesis of novel substituted titanocenes via reductive dimerisation, carbolithiation or hydridolithiation reactions, which are followed by a transmetallation reaction with titanium tetrachloride in the latter two cases. Depending on the substitution pattern, these titanocenes prove to be bioorganometallic anti-cancer drugs, which have significant potential against advanced or metastatic renal-cell cancer. Patients bearing these stages of kidney cancer have a poor prognosis so far and therefore real progress in the area of metal-based anti-cancer drugs may come from this simple and effective synthetic approach. This tutorial review provides an insight into the synthesis of fulvene-derived titanocenes and their activity in preclinical experiments.

• Authors: Katja Strohfeldt, Matthias Tacke
• Journal: Chemical Society reviews (Chem Soc Rev) Vol. 37 Issue 6 Pg. 1174-87 (Jun 2008) ISSN: 0306-0012 [Print] England
• PMID: 18497930 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Cyclopentanes
• Organometallic Compounds
• titanocene
• fulvene

Topics

• Animals
• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Survival (drug effects)
• Cyclopentanes (chemistry)
• Drug Screening Assays, Antitumor
• Inhibitory Concentration 50
• Kidney Neoplasms (drug therapy)
• LLC-PK1 Cells
• Molecular Structure
• Organometallic Compounds (chemical synthesis, chemistry, pharmacology)
• Swine