Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry.

Abstract

Chen et al. found that the CA haplotype of protein C -1654C/T and -1641G/A was associated with increased risk of death and organ dysfunction in Chinese Han patients with severe sepsis (Hum Genet 123:281-287, 2008). We similarly tested for association of the C allele of protein C 673 T/C (rs2069912) (linkage disequilibrium with the CA haplotype, D' = 100%) in a cohort of 100 North American East Asians with severe sepsis. The C allele was associated with increased mortality and organ dysfunction, consistent with Chen et al.

• Authors: James A Russell, Hugh Wellman, Keith R Walley
• Journal: Human genetics (Hum Genet) Vol. 123 Issue 6 Pg. 661-3 (Jul 2008) ISSN: 1432-1203 [Electronic] Germany
• PMID: 18496716 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Protein C

Topics

• Aged
• Alleles
• Asian People (genetics)
• Asia, Eastern (ethnology)
• Female
• Gene Frequency
• Haplotypes
• Humans
• Male
• Middle Aged
• Multiple Organ Failure (etiology, genetics, mortality)
• North America (epidemiology)
• Polymorphism, Single Nucleotide
• Protein C (genetics)
• Sepsis (complications, genetics, mortality)