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Chemical sympathectomy increases susceptibility to ocular herpes simplex virus type 1 infection.

Abstract
The cornea is one of the most highly innervated tissues in the mammalian host. We hypothesized changes to cornea innervation through chemical sympathectomy would significantly alter the host response to the neurotropic viral pathogen, herpes simplex virus type 1 (HSV-1) following ocular infection. Mice treated with 6-hydroxydopamine hydrobromide displayed reduced tyrosine hydroxylase-positive fibers residing in the cornea. Sympathectomized mice were also found to show a transient rise in virus recovered in infected tissues and succumbed to infection in greater numbers. Whereas there were no differences in infiltrating leukocyte populations including HSV-1-specific cytotoxic T lymphocytes in the infected tissue, an increase in substance P and a decrease in IFN-gamma levels in the trigeminal ganglion but not brain stem of sympathectomized mice were noted. Sympathectomized mice treated with the neurokinin-1 receptor antagonist L703,606 had delayed mortality implicating the involvement of substance P in HSV-1-mediated death.
AuthorsAmanda Templeton, Gabrielle Nguyen, John D Ash, Rainer H Straub, Daniel J J Carr
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 197 Issue 1 Pg. 37-46 (Jun 15 2008) ISSN: 0165-5728 [Print] Netherlands
PMID18495255 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Substance P
  • Interferon-gamma
  • Oxidopamine
  • Tyrosine 3-Monooxygenase
Topics
  • Animals
  • Brain Stem (drug effects, metabolism)
  • Cell Line, Tumor
  • Cornea (drug effects, enzymology, innervation)
  • Disease Susceptibility (immunology)
  • Female
  • Herpesvirus 1, Human (immunology)
  • Interferon-gamma (antagonists & inhibitors, metabolism)
  • Keratitis, Herpetic (immunology, metabolism, pathology)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Nerve Fibers (drug effects, enzymology)
  • Oxidopamine
  • Substance P (biosynthesis)
  • Sympathectomy, Chemical (adverse effects)
  • T-Lymphocytes, Cytotoxic (immunology, pathology)
  • Trigeminal Ganglion (drug effects, immunology, metabolism)
  • Tyrosine 3-Monooxygenase (antagonists & inhibitors, biosynthesis)
  • Up-Regulation (drug effects, immunology)

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