Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literature.

Abstract

Myogenin immunostaining has been described as a useful marker of the alveolar subtype of rhabdomyosarcoma and as a tool for distinguishing it from the more common embryonal subtype. To add to the growing body of literature describing this phenomenon we analysed myogenin immunohistochemical staining in 152 tumors using a rhabdomyosarcoma tissue array. Results were analysed blinded to histological type by two independent investigators. Samples were excluded if any samples failed to stain with desmin and/or myogenin. Mean percentage of myogenin positive cells was significantly greater for ARMS (n = 31; mean percentage positivity 59% (95% confidence intervals +/- 7%) than ERMS (n = 41, mean percentage positivity 16%, 95% confidence intervals +/- 4; P < 0.0001). This data is consistent with previously published studies identifying strong nuclear myogenin staining in a high proportion of cells as a marker of alveolar histology.

• Authors: D A Morgenstern, H Rees, N J Sebire, J Shipley, John Anderson
• Journal: Pathology oncology research : POR (Pathol Oncol Res) Vol. 14 Issue 3 Pg. 233-8 (Sep 2008) ISSN: 1219-4956 [Print] Switzerland
• PMID: 18493875 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Biomarkers, Tumor
• Myogenin

Topics

• Biomarkers, Tumor (metabolism)
• Diagnosis, Differential
• Humans
• Myogenin (metabolism)
• Prognosis
• Rhabdomyosarcoma, Alveolar (classification, diagnosis, metabolism)
• Rhabdomyosarcoma, Embryonal (classification, diagnosis, metabolism)
• Sensitivity and Specificity
• Tissue Array Analysis