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A case of mixed connective tissue disease complicated with hypertrophic obstructive cardiomyopathy.

Abstract
A 54-year-old female was diagnosed as mixed connective tissue disease (MCTD) complicated with secondary Sjögren's syndrome. Although she had no dyspnea on exertion, the chest X-ray showed cardiomegaly with interstitial pneumonia. The echocardiogram demonstrated asymmetric hypertrophy of the interventricular septum. Diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) was confirmed by left ventriculography and myocardial biopsy. She was treated with prednisolone, resulting in improvement of swollen hand, elevated muscle enzymes and interstitial pneumonia. A rare complication of HOCM with MCTD was described.
AuthorsHideki Nakamura, Seiko Tateishi, Atsushi Kawakami, Hiroaki Ida, Taku Fukuda, Michiyo Sasaki, Yuji Koide, Naoto Ashizawa, Shinji Seto, Tomayoshi Hayashi, Shinichi Sato, Katsumi Eguchi
JournalRheumatology international (Rheumatol Int) Vol. 28 Issue 12 Pg. 1273-5 (Oct 2008) ISSN: 0172-8172 [Print] Germany
PMID18493766 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • HLA-DR4 Antigen
  • Prednisolone
Topics
  • Anti-Inflammatory Agents (therapeutic use)
  • Cardiomyopathy, Hypertrophic (complications, drug therapy, pathology)
  • Female
  • HLA-DR4 Antigen (immunology)
  • Humans
  • Lung Diseases, Interstitial (etiology)
  • Middle Aged
  • Mixed Connective Tissue Disease (complications, drug therapy)
  • Prednisolone (therapeutic use)
  • Sjogren's Syndrome (complications, drug therapy)

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