With the advance of gastrointestinal endoscopy, pill-induced
esophagitis has been detected more frequently, but the association of mucosal dissection is rare. We reported a case of pill-induced
esophagitis associated with mucosal dissection.A 66-year-old male with combined
valvular heart disease was admitted for cardiac surgery.
Cefotiam hydrochloride tablet was administered for
postoperative wound infection of cardiac surgery. Next morning severe odynophagia and retrosternal
pain were occurred. Upper gastrointestinal endoscopy performed 2 days after onset of the symptom showed detached mucosa at the upper thoracic esophagus and acute
esophagitis at middle and lower thoracic esophagus. Histological examination of the mucosa revealed that the esophageal mucosa was detached from the lamina propria. After the treatment for
esophagitis, almost normal esophageal mucosa covered the esophagus without
scarring or
stricture.The present case was diagnosed as
cefotiam hydrochloride tablet induced
esophagitis because of the onset of this disease. Mucosal dissection of the esophagus may be associated with both the
esophagitis and
bleeding tendencies caused by
anticoagulant therapy.