HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Flow cytometric analysis of nuclear DNA content in gestational trophoblastic disease.

Abstract
Flow cytometric analysis of nuclear DNA is a quick and accurate method of determining nuclear ploidy. This technique allows a clear distinction to be made between diploid and triploid hydatidiform moles. Additional ploidy aberrations, such as tetraploidy and aneuploidy, have also been reported in flow cytometric studies of hydatidiform moles. Recent investigations have suggested that aneuploidy in complete hydatidiform moles is associated with a high risk of persistent gestational trophoblastic disease. In addition to DNA ploidy analysis, cell cycle activity may be calculated from analysis of the DNA histogram. No significant correlation between clinical course and cell cycle kinetics has been demonstrated to date. By providing valuable DNA ploidy data, flow cytometric studies of hydatidiform moles may be helpful in the identification of patients at high risk of postmolar trophoblastic sequelae.
AuthorsJ M Lage
JournalThe Journal of reproductive medicine (J Reprod Med) Vol. 36 Issue 1 Pg. 31-5 (Jan 1991) ISSN: 0024-7758 [Print] UNITED STATES
PMID1848897 (Publication Type: Journal Article)
Chemical References
  • DNA
Topics
  • DNA (chemistry)
  • Female
  • Flow Cytometry (methods, standards)
  • Humans
  • Ploidies
  • Predictive Value of Tests
  • Pregnancy
  • Prognosis
  • Reproducibility of Results
  • Risk Factors
  • Trophoblastic Neoplasms (chemistry, epidemiology, genetics)
  • Uterine Neoplasms (chemistry, epidemiology, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: