[Effect of 11-deoxymisoprostol ethyl ether sodium salt on thrombocyte aggregation and prothrombin time].

Abstract

11-Deoxymisoprostol demonstrates antiaggregant properties with respect to the adrenalin-, collagen-, and ADP-induced aggregation of thrombocytes, which is manifested by a decrease in the rate of blood platelet agglutination and their secretion, and by an increase in the time of thrombus formation.

• Authors: S F Gabdrakhmanova, N S Makara, T V Sapozhnikova, N Zh Baschenko, V S Nazarov, F S Zarudiĭ
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2008 Mar-Apr Vol. 71 Issue 2 Pg. 40-2 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 18488906 (Publication Type: English Abstract, Journal Article)

Chemical References

• 2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol
• Platelet Aggregation Inhibitors
• Misoprostol
• Adenosine Diphosphate
• Collagen
• Epinephrine

Topics

• Adenosine Diphosphate (metabolism)
• Blood Platelets (drug effects, physiology)
• Collagen (metabolism)
• Epinephrine (pharmacology)
• Humans
• In Vitro Techniques
• Misoprostol (analogs & derivatives, pharmacology)
• Platelet Aggregation (drug effects, physiology)
• Platelet Aggregation Inhibitors (pharmacology)
• Prothrombin Time