[A case of advanced gastric cancer with Schnitzler's metastases effectively treated by the combination of paclitaxel and S-1].

Abstract

The patient was a 70-year-old woman who underwent combined chemotherapy of paclitaxel (PTX) and S-1 after diagnosis of non-resectable advanced gastric cancer with Schnitzler's metastases. The administration schedule was as follows: 120 mg/m(2) of PTX on days 1 and 15 intravenously and 80 mg/m(2) of S-1 on days 1-14 orally. One course lasted for 4 weeks. The abdominal pain and appetite loss improved after the first course of chemotherapy, and therapeutic efficacy was rated PR. At present, there is no evidence of relapse or adverse reactions that require intervention after 4 courses. PTX and S-1 combination treatment promises good therapeutic efficacy and improves QOL in patients with advanced gastric cancer associated with Schnitzler's metastases.

• Authors: Manabu Yamamoto, Ayumi Matsuyama, Toshifumi Kameyama, Masahiro Okamoto, Jin Okazaki, Tohru Utsunomiya, Shinichi Tsutsui, Teruyoshi Ishida
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 5 Pg. 829-31 (May 2008) ISSN: 0385-0684 [Print] Japan
• PMID: 18487923 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Antineoplastic Agents, Phytogenic
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Paclitaxel

Topics

• Aged
• Antimetabolites, Antineoplastic (administration & dosage)
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Drug Administration Schedule
• Drug Combinations
• Female
• Humans
• Oxonic Acid (administration & dosage)
• Paclitaxel (administration & dosage)
• Peritoneal Neoplasms (secondary)
• Stomach Neoplasms (drug therapy, pathology)
• Tegafur (administration & dosage)