Some prognostic factors for the development of transplant-related coronary artery disease in human cardiac allografts.

Abstract

The study of endomyocardial biopsy specimens taken in the first 130 days after transplantation has yielded no histologic features predictive of later development of transplant-related coronary artery disease. This study, however, indicated that a combination of the following factors might be predictive in cyclosporine-treated patients: untreated histologically proven episodes of rejection, infection with cytomegalovirus or reactivation of infection, ischemic heart disease in the recipient as the reason for heart transplantation, and possibly HLA-B5 or -B8 mismatch.

• Authors: P G Stovin, L Sharples, J A Hutter, J Wallwork, T A English
• Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transplant) 1991 Jan-Feb Vol. 10 Issue 1 Pt 1 Pg. 38-44 ISSN: 1053-2498 [Print] United States
• PMID: 1848788 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cyclosporins
• HLA-B Antigens

Topics

• Adult
• Biopsy
• Coronary Artery Disease (complications)
• Coronary Disease (etiology, mortality, pathology)
• Cyclosporins (therapeutic use)
• Cytomegalovirus Infections (complications)
• Female
• Graft Rejection
• HLA-B Antigens (analysis)
• Heart Transplantation (adverse effects)
• Humans
• Male
• Myocardium (pathology)
• Prognosis
• Risk Factors
• Time Factors