Abstract | CONTEXT: OBJECTIVE: To update the previous review on smart drugs published in the European Journal in 2006 (Patard JJ, et al. Understanding the importance of smart drugs in renal cell carcinoma. Eur Urol 2006; 49:633-43). EVIDENCE ACQUISITION: Critical review of published literature 2006-2008 (Pubmed website search words: renal cell carcinoma and/or targeted therapy and prospective trials) and more recent meeting abstracts (American Society of Clinical Oncology 2007). Quality assessment included prospective phase I-III trials and critical evaluations with low numbers of patients, retrospective analyses, and slide presentations of meeting abstracts. EVIDENCE SYNTHESIS: This review presents the current situation and provides more recent data on sequential treatment, the association of targeted drugs, and the treatment of non-clear-cell histologies. CONCLUSIONS: Treatment of mRCC with targeted therapy centers on at least two major pathways: angiogenesis and mTOR involving inhibiting drugs that may be used alone, in combination, or sequentially.
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Authors | Alain Ravaud, Hervé Wallerand, Stéphane Culine, Jean-Christophe Bernhard, Patricia Fergelot, Karim Bensalah, Jean-Jacques Patard |
Journal | European urology
(Eur Urol)
Vol. 54
Issue 2
Pg. 315-25
(Aug 2008)
ISSN: 1873-7560 [Electronic] Switzerland |
PMID | 18485581
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Vascular Endothelial Growth Factor A
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Topics |
- Antineoplastic Agents
(therapeutic use)
- Carcinoma, Renal Cell
(drug therapy, metabolism, secondary)
- Cell Hypoxia
(drug effects)
- Humans
- Kidney Neoplasms
(drug therapy, metabolism, pathology)
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
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