Abstract | BACKGROUND AND OBJECTIVE: METHODS: Sixty patients who underwent varicocoele surgery were randomly assigned to three different treatment groups. Before skin closure, patients received the following treatments: group I (n=20) patients received normal saline 20 mL wound infiltration and intravenous lornoxicam (Xefo, Nycomed Pharma AS, Roskilde, Denmark) 2 mL (8 mg); group II (n=20) patients received 0.25% levobupivacaine ( Chirocaine, Abbott Scandinavia AB, Solna, Sweden) 10mL with normal saline 10 mL wound infiltration and intravenous normal saline 2 mL; group III (n=20) patients received 0.25% levobupivacaine 10 mL with normal saline 10 mL wound infiltration and intravenous lornoxicam 2 mL (8 mg). Pain scores and total pethidine ( meperidine) consumption were measured at 1, 2, 4, 6, 12 and 24 hours postoperatively. Time to first analgesic requirement and patient satisfaction were also compared post-surgery. RESULTS:
Pain scores during the first 6 hours postoperatively were significantly lower in group III than in group I and group II (p<0.01). Total pethidine consumption was significantly lower in group III (34.0+/-28.0 mg) than in group I (74.0+/-25 mg) and group II (76.0+/-29 mg) [p<0.01]. Time to first analgesic was also significantly longer in group III (14.8+/-8.4 hours) than in group I (6.2+/-5.2 hours) and group II (5.8+/-7.1 hours) [p<0.01]. The incidence of postoperative nausea and vomiting was significantly lower in group III than in group I and group II (p<0.05). More patients in group III described their analgesia as good or excellent than in group I or group II (p<0.01). CONCLUSION:
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Authors | Dilek Memis, Sevtap Hekimoglu, Gaye Kaya, Huseyin I Atakan, Mustafa Kaplan |
Journal | Clinical drug investigation
(Clin Drug Investig)
Vol. 28
Issue 6
Pg. 353-9
( 2008)
ISSN: 1173-2563 [Print] New Zealand |
PMID | 18479177
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anesthetics, Local
- Anti-Inflammatory Agents, Non-Steroidal
- Piroxicam
- Levobupivacaine
- lornoxicam
- Bupivacaine
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Topics |
- Adult
- Anesthetics, Local
(administration & dosage)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Bupivacaine
(administration & dosage, adverse effects, analogs & derivatives)
- Double-Blind Method
- Drug Therapy, Combination
- Humans
- Levobupivacaine
- Male
- Pain, Postoperative
(drug therapy)
- Piroxicam
(administration & dosage, adverse effects, analogs & derivatives)
- Varicocele
(surgery)
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