Abstract | BACKGROUND AND OBJECTIVE: METHODS: The hot-plate test consisted of placing individual mice (adult male Balb/C) on the hot plate at 50+/-0.1 degrees C and timing the delay for the first hind paw lift (nociceptive threshold). After obtaining control values, diabetes was induced by injection of streptozotocin [200 mg/kg intraperitoneally (i.p.)] and 2 weeks after induction of diabetes (serum glucose > or =400 mg/dL) LEV was administered i.p. and hot-plate tests were repeated. Pain threshold values were determined and analyzed by Kruskal-Wallis one-way analysis of variance (ANOVA) followed by a pairwise comparison using a Dunnett's t-test on the ranked data. RESULTS: LEV (60, 300 and 900 mg/kg) had no significant effect on the nociceptive threshold in normal mice (n=8 for each dose, P>0.05). There were significant decreases in pain threshold latency in diabetic mice compared with the normal healthy group and these were significantly and dose-dependently restored by much lower doses of LEV (20, 100 and 200 mg/kg) in a reversible manner. CONCLUSION: Results obtained from the in vivo behavioral test lend support to the validation of the promising therapeutic potential of the novel antiepileptic agent LEV in the treatment of neuropathic pain.
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Authors | M Ozcan, A Ayar, S Canpolat, S Kutlu |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 52
Issue 7
Pg. 926-30
(Aug 2008)
ISSN: 1399-6576 [Electronic] England |
PMID | 18477089
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Anticonvulsants
- Levetiracetam
- Piracetam
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Topics |
- Analgesics
(therapeutic use)
- Animals
- Anticonvulsants
(therapeutic use)
- Behavior, Animal
(drug effects)
- Diabetic Neuropathies
(drug therapy)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Hot Temperature
- Levetiracetam
- Male
- Mice
- Mice, Inbred BALB C
- Pain
(drug therapy)
- Pain Measurement
(methods, statistics & numerical data)
- Piracetam
(analogs & derivatives, therapeutic use)
- Time Factors
- Treatment Outcome
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