[Effect of Qishen Huoxue Granule in treating severe sepsis].

Abstract

OBJECTIVE:

To study the anti-inflammatory effect and the therapeutic efficacy of Qishen Huoxue Granule (QHG) in treating severe sepsis.

METHODS:

One hundred and sixty-seven patients with severe sepsis were enrolled and randomly assigned to two groups, the 85 patients in the control group treated with conventional Western medicine and the 82 in the QHG group treated with conventional Western medicine plus QHG. Changes of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), procalcitonin (PCT), Marshall score, APACHE II score, ICU stay time and 28-day mortality were monitored and compared.

RESULTS:

Compared with the control group, IL-6 and TNF-alpha levels, the ICU stay time and 28-day mortality were significantly lower in the QHG group (all P < 0.05). During the QHG treatment, no severe adverse event was observed.

CONCLUSION:

The integrative treatment could reduce the blood levels of IL-6 and TNF-alpha, shorten the ICU stay time and decrease the 28-day mortality of patients with sepsis, showing a favor therapeutic prospect.

• Authors: Yan-Li Su, Hong Wang, Shu-Wen Zhang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 28 Issue 3 Pg. 209-11 (Mar 2008) ISSN: 1003-5370 [Print] China
• PMID: 18476417 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Interleukin-6
• Tumor Necrosis Factor-alpha
• qishen huoxue

Topics

• Aged
• Aged, 80 and over
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Humans
• Interleukin-6 (blood)
• Male
• Middle Aged
• Phytotherapy
• Sepsis (blood, drug therapy, pathology)
• Treatment Outcome
• Tumor Necrosis Factor-alpha (blood)