| Abstract | Diphenylantimony(III) and diorganotin(IV) derivatives of dithiophosphorus ligands, i.e. Ph(2)SbS(2)PR'(2) (R' = Ph, OPr-i) and R(2)Sn(S(2)PR'(2))(2) (R = n-Bu, Ph, R' = Ph; R = Ph, R' = OPr-i), have been screened against P388 leukemia in mice. All the compounds showed marginal activity towards this tumor system, some of them increasing the life span of the animals with more than 20%. The best results were obtained with (di-iso-propylphosphorodithioato)diphenylantimony(III) which exhibited a T/C value of 136%, at a dose of 5 mg/kg, administered on days 1,2 and 3 after tumor transplantation. |
| Authors | B K Keppler, C Silvestru, I Haiduc
(Affiliation: Anorganisch-Chemisches Institut der Universität Heidelberg In Neuenheimer Feld 270 Heidelberg 1 D-6900 Germany.)
|
| Journal | Metal-based drugs
(Met Based Drugs)
Vol. 1
Issue 1
Pg. 73-7
( 1994)
ISSN: 0793-0291 United States |
| PMID | 18476218
(Publication Type: Journal Article)
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