Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils.

Abstract

The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg(-1)) markedly promoted the recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to an increase of the activity of endogenous superoxide dismutase.

• Authors: Ling Li, Zhiqiang Shen, Weimin Yang, Wanling Wu, Weiping Liu, Zhihe Chen
• Journal: Metal-based drugs (Met Based Drugs) Vol. 8 Issue 5 Pg. 253-6 ( 2002) ISSN: 0793-0291 [Print] United States
• PMID: 18476002 (Publication Type: Journal Article)