| Abstract | Objective: The purpose of this study was to investigate the efficacy of 200 mg of prophylactic doxycycline in preventing pelvic infection after curettage for spontaneous (incomplete) abortion.Methods: A randomized, prospective, double-blinded study was carried out involving 300 women with an incomplete abortion who were given either placebo or 200 mg of doxycycline orally 30-60 min prior to curettage. A hematocrit, WBC count, pregnancy test, syphilis serology, Neisseria gonorrhoeae culture, and Micro Trak (monoclonal antibody test, Syba, San Jose, CA) for Chlamydia trachomatis were performed. The patients were scheduled for follow-up 2 weeks later. Antibiotic administration for any reason as well as the postoperative infection rate in these women was assessed.Results: Eleven women were excluded from analysis, leaving 289 evaluable. N. gonorrhoeae was isolated from 6 (2%) women and C. trachomatis from 8 (3%) women, and the syphilis serology was serofast in 4 (1%) women. Endometritis complicated the procedure in 4 women who received placebo and in 1 woman who received doxycycline (P = 0.22).Conclusion: Prophylactic doxycycline is not effective in preventing pelvic infection after curettage for spontaneous (incomplete) abortion. |
| Authors | K D Ramin, S M Ramin, P G Hemsell, B J Nobles, M C Heard, V B Johnson, D L Hemsell
(Affiliation: Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center Parkland Memorial Hospital 5323 Harry Hines Boulevard Dallas TX 75235-9032 USA.)
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| Journal | Infectious diseases in obstetrics and gynecology
(Infect Dis Obstet Gynecol)
Vol. 2
Issue 5
Pg. 213-7
( 1995)
ISSN: 1064-7449 Egypt |
| PMID | 18475395
(Publication Type: Journal Article)
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