| Abstract | Objective: This study was undertaken to determine plasma and pelvic tissue concentrations of piperacillin/tazobactam following a single intravenous administration.Methods: Plasma and tissue samples were obtained following administration of 3 g of piperacillin and 0.375 g of tazobactam. Concentrations of these agents were determined by chromatography.Results: Plasma concentrations (mean +/-SD) for piperacillin/tazobactam were 208 +/- 87/27 +/- 8 and 95 +/- 53/14 +/- 2, respectively, at 30 and 60 min after the start of the infusion. The 8:1 ratio between piperacillin and tazobactam in plasma remained constant for up to 96 min. Tissue concentrations yielded a broader range, but each agent achieved significant penetration in each of the tissues studied.Conclusions: Piperacillin/tazobactam demonstrates favorable penetration in female genital tract tissues and Should be considered a potentially effective agent for female pelvic infections. |
| Authors | W F O'Brien, S George
(Affiliation: Division of Obstetrics University of South Florida College of Medicine Suite 506, 4 Columbia Drive Tampa FL 33606 USA.)
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| Journal | Infectious diseases in obstetrics and gynecology
(Infect Dis Obstet Gynecol)
Vol. 2
Issue 1
Pg. 20-4
( 1994)
ISSN: 1064-7449 Egypt |
| PMID | 18475361
(Publication Type: Journal Article)
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