Methylphenidate in children with oppositional defiant disorder and both comorbid chronic multiple tic disorder and ADHD.

Our primary objective was to determine if immediate-release methylphenidate is an effective treatment for oppositional defiant disorder diagnosed from mother's report in children with both chronic multiple tic disorder and attention-deficit hyperactivity disorder (ADHD). Children (n = 31) aged 6 to 12 years received placebo and 3 doses of methylphenidate twice daily for 2 weeks each under double-blind conditions and were assessed with ratings scales and laboratory measures. Results indicated significant improvement in both oppositional and ADHD behaviors with medication; however, the magnitude of treatment effect varied considerably as a function of disorder (ADHD > Oppositional behaviors), informant (teacher > mother), assessment instrument, and specific oppositional behavior (rebellious > disobeys rules). Drug response was comparable with that in children (n = 26) who did not have diagnosed oppositional defiant disorder, but comorbidity appeared to alter the perceived benefits for ADHD according to mother's report. Methylphenidate is an effective short-term treatment for oppositional behavior in children with comorbid ADHD and chronic multiple tic disorder.
AuthorsKenneth D Gadow, Edith E Nolan, Jeffrey Sverd, Joyce Sprafkin, Jayne Schneider
JournalJournal of child neurology (J Child Neurol) Vol. 23 Issue 9 Pg. 981-90 (Sep 2008) ISSN: 1708-8283 [Electronic] United States
PMID18474932 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Central Nervous System Stimulants
  • Placebos
  • Methylphenidate
  • Age Factors
  • Aggression (drug effects)
  • Attention Deficit Disorder with Hyperactivity (complications, drug therapy)
  • Attention Deficit and Disruptive Behavior Disorders (complications, drug therapy)
  • Central Nervous System Stimulants (administration & dosage)
  • Child
  • Comorbidity
  • Disability Evaluation
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Humans
  • Male
  • Methylphenidate (administration & dosage)
  • Neuropsychological Tests
  • Placebos
  • Sex Factors
  • Tic Disorders (complications, drug therapy)
  • Treatment Outcome

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