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Plasma B-cell tropin (ACTH22-39) concentration in lean and obese (ob/ob) mice and lean and obese (fa/fa) Zucker rats.

Abstract
A method has been developed for the measurement of plasma concentrations of Beta-cell tropin (BCT), which is a potent insulinotropic and lipogenic peptide secreted by the pituitary. The method was employed to compare plasma Beta-cell tropin concentrations between lean and genetically obese (ob/ob) mice and between lean and genetically obese (fa/fa) Zucker rats. The plasma concentration in lean mice was 0.17 +/- 0.02 (5)nmole/l (mean +/- SEM, n = 5), while that in obese (ob/ob) mice was significantly higher, being 2.88 +/- 1.13 (5)nmole/l. The plasma BCT concentration in Zucker rats was 0.14 +/- 0.02 (15)nmole/l, while that in obese Zucker (fa/fa) rats was significantly higher, being 1.69 +/- 0.72 (16)nmole/l. These results explain previously observed differences in the Beta-cell tropin-like biological activity in plasma from lean and obese animals, and support the hypothesis that the peptide has a role in the development of hyperinsulinaemia and obesity.
AuthorsJ L Morton, M Davenport, S J Dunmore
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 174 Issue 2 Pg. 767-71 (Jan 31 1991) ISSN: 0006-291X [Print] United States
PMID1847053 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Peptide Fragments
  • beta-cell tropin
  • Adrenocorticotropic Hormone
Topics
  • Acetylation
  • Adrenocorticotropic Hormone (blood, isolation & purification)
  • Animals
  • Chromatography, High Pressure Liquid
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Obese (blood)
  • Peptide Fragments (blood, isolation & purification)
  • Radioimmunoassay
  • Rats
  • Rats, Zucker (blood)
  • Reference Values

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