The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.

Abstract	An ideal vaccination strategy against tumors relies on specific antigens that are required for tumor maintenance. For lymphoma, vaccination with subject-specific immunoglobulin idiotypes has had the most promising results. Here we show that DNA vaccination with plasmids encoding portions of the cytoplasmic domain of anaplastic lymphoma kinase (ALK), which has been translocated in different fusion proteins necessary for the growth of anaplastic large cell lymphoma (ALCL), protects mice from local and systemic lymphoma growth. The protection is potent and long lasting and elicits ALK-specific interferon-gamma responses and CD8+ T cell-mediated cytotoxicity. A combination of chemotherapy and vaccination significantly enhanced the survival of mice challenged with ALK+ lymphomas. These findings indicate that ALK represents an ideal tumor antigen for vaccination-based therapies of ALCL and possibly other ALK+ human tumors.
Authors	Roberto Chiarle, Cinzia Martinengo, Cristina Mastini, Chiara Ambrogio, Valentina D'Escamard, Guido Forni, Giorgio Inghirami
Journal	Nature medicine (Nat Med) Vol. 14 Issue 6 Pg. 676-80 (Jun 2008) ISSN: 1546-170X [Electronic] United States
PMID	18469826 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References	Antigens, Neoplasm Fluorescent Dyes ALK protein, human Alk protein, mouse Anaplastic Lymphoma Kinase Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases Fluorescein-5-isothiocyanate
Topics	Anaplastic Lymphoma Kinase Animals Antigens, Neoplasm (immunology, therapeutic use) Cell Line, Transformed Cell Line, Tumor Cell Transformation, Neoplastic Fluorescein-5-isothiocyanate (metabolism) Fluorescent Antibody Technique, Direct Fluorescent Dyes (metabolism) Immunization, Secondary Immunohistochemistry Lymphoma, Large-Cell, Anaplastic (immunology, pathology, therapy) Mice Mice, Inbred BALB C Mice, Transgenic Mutation Plasmids Protein-Tyrosine Kinases (genetics, immunology) Receptor Protein-Tyrosine Kinases Vaccination

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