Abstract | AIM OF THE STUDY: The fruits of Forsythia koreana have long been used in Chinese medicine to treat inflammatory disorders. However, the pharmacological data is not sufficient to clearly establish a scientific rationale for the anti-inflammatory medicinal use of this plant material, and the search for its active principles has been limited so far. MATERIALS AND METHODS:
Phylligenin ( lignan) was isolated from the fruits of Forsythia koreana and its anti-inflammatory activity was examined. RESULTS AND CONCLUSION:
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Authors | Hyun Lim, Jong Gu Lee, Seung Ho Lee, Yeong Shik Kim, Hyun Pyo Kim |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 118
Issue 1
Pg. 113-7
(Jun 19 2008)
ISSN: 0378-8741 [Print] Ireland |
PMID | 18467047
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Lignans
- NF-kappa B
- Plant Extracts
- phylligenin
- Nitric Oxide
- Nitric Oxide Synthase Type II
- Cyclooxygenase 2
- Dinoprostone
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Topics |
- Animals
- Anti-Inflammatory Agents
(administration & dosage, isolation & purification, pharmacology)
- Cyclooxygenase 2
(drug effects, metabolism)
- Dinoprostone
(metabolism)
- Dose-Response Relationship, Drug
- Forsythia
(chemistry)
- Fruit
- Inflammation
(drug therapy, metabolism)
- Lignans
(administration & dosage, isolation & purification, pharmacology)
- Male
- Medicine, Chinese Traditional
- Mice
- Mice, Inbred ICR
- NF-kappa B
(drug effects, metabolism)
- Nitric Oxide
(biosynthesis)
- Nitric Oxide Synthase Type II
(drug effects, metabolism)
- Plant Extracts
(administration & dosage, pharmacology)
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