HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Anti-inflammatory activity of phylligenin, a lignan from the fruits of Forsythia koreana, and its cellular mechanism of action.

AbstractAIM OF THE STUDY:
The fruits of Forsythia koreana have long been used in Chinese medicine to treat inflammatory disorders. However, the pharmacological data is not sufficient to clearly establish a scientific rationale for the anti-inflammatory medicinal use of this plant material, and the search for its active principles has been limited so far.
MATERIALS AND METHODS:
Phylligenin (lignan) was isolated from the fruits of Forsythia koreana and its anti-inflammatory activity was examined.
RESULTS AND CONCLUSION:
Phylligenin (1-100 microM) and the methanol extract of Forsythia koreana fruits inhibited cyclooxygenase-2 (COX-2)-mediated prostaglandin E(2) and inducible nitric oxide synthase (iNOS)-mediated nitric oxide (NO) synthesis from lipopolysaccharide-treated RAW 264.7 cells. In the mechanism study, phylligenin inhibited iNOS expression and nuclear factor-kappaB (NF-kappaB) activation but had no effect on COX-2 expression. Moreover, phylligenin significantly inhibited mouse carrageenan-induced paw edema by intraperitoneal administration (22.1-34.7% inhibition at 12.5-100 mg/kg). These pharmacological properties indicate that phylligenin possesses significant anti-inflammatory activity in vitro and in vivo, and may provide the scientific rationale for anti-inflammatory use of the fruits of Forsythia koreana.
AuthorsHyun Lim, Jong Gu Lee, Seung Ho Lee, Yeong Shik Kim, Hyun Pyo Kim
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 118 Issue 1 Pg. 113-7 (Jun 19 2008) ISSN: 0378-8741 [Print] Ireland
PMID18467047 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Lignans
  • NF-kappa B
  • Plant Extracts
  • phylligenin
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Cyclooxygenase 2
  • Dinoprostone
Topics
  • Animals
  • Anti-Inflammatory Agents (administration & dosage, isolation & purification, pharmacology)
  • Cyclooxygenase 2 (drug effects, metabolism)
  • Dinoprostone (metabolism)
  • Dose-Response Relationship, Drug
  • Forsythia (chemistry)
  • Fruit
  • Inflammation (drug therapy, metabolism)
  • Lignans (administration & dosage, isolation & purification, pharmacology)
  • Male
  • Medicine, Chinese Traditional
  • Mice
  • Mice, Inbred ICR
  • NF-kappa B (drug effects, metabolism)
  • Nitric Oxide (biosynthesis)
  • Nitric Oxide Synthase Type II (drug effects, metabolism)
  • Plant Extracts (administration & dosage, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: