Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats.

Abstract

In the present study, we have investigated the neuroprotective potential of ginsenoside Re (Re) in the middle cerebral artery occlusion model in Sprague-Dawley rats. Adult male Sprague-Dawley rats were treated with Re (5, 10 or 20 mg kg(- 1), P.O. for 7 days, once a day) prior to occlusion. There was a significant increase in the neurological symptoms in ischemic animals as compared with the sham group animals. These effects were attenuated by 10 and 20 mg kg(- 1) Re, P.O. There was a significant increase in the level of malondialdehyde (MDA) in ischemic animals indicating oxidative stress. An elevated level of MDA in ischemic animals was reduced by 10 and 20 mg kg(- 1) Re, P.O., respectively. It was observed that Re significantly decreased mitochondrial swelling, thereby preventing the reduction of H(+)-ATPase activity. This study demonstrates the neuroprotective potential of Re in cerebral ischemia-reperfusion injury in rats.

• Authors: Li-Min Chen, Xiao-Mian Zhou, Ying-Lin Cao, Wen-Xiang Hu
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) 2008 May-Jun Vol. 10 Issue 5-6 Pg. 439-45 ISSN: 1028-6020 [Print] England
• PMID: 18464084 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Ginsenosides
• Neuroprotective Agents
• ginsenoside Re
• Malondialdehyde
• Proton-Translocating ATPases

Topics

• Animals
• Brain Ischemia (drug therapy)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Ginsenosides (pharmacology, therapeutic use)
• Lipid Peroxidation (drug effects)
• Male
• Malondialdehyde (metabolism)
• Mitochondrial Swelling (drug effects)
• Neuroprotective Agents (pharmacology, therapeutic use)
• Phytotherapy
• Proton-Translocating ATPases (metabolism)
• Rats
• Rats, Sprague-Dawley
• Reperfusion Injury (drug therapy)