Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone A.

Abstract

In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.

• Authors: Gerhard Bringmann, Tobias A M Gulder, Gerhard Lang, Stefanie Schmitt, Rüdiger Stöhr, Jutta Wiese, Kerstin Nagel, Johannes F Imhoff
• Journal: Marine drugs (Mar Drugs) Vol. 5 Issue 2 Pg. 23-30 (Jun 25 2007) ISSN: 1660-3397 [Electronic] Switzerland
• PMID: 18463724 (Publication Type: Journal Article)