Abstract |
Bovine serum albumin (BSA) glomerulonephritis is a type of immune complex glomerulonephritis that is characterized by a large number of leukocytes infiltrating the kidney. Interleukin (IL)-18, which has potent interferon (IFN)-gamma-inducing activities, may play an important role in lymphocyte-mediated inflammatory responses. To investigate the role of IL-18 in BSA glomerulonephritis, we used IL-18R-deficient C57BL/6 mice. Compared with control mice, IL-18R-deficient mice showed a significant reduction of proteinuria, renal pathological findings including glomerular IgG and C3 deposits, and leukocyte infiltrates. Transcripts encoding IFN-gamma and tumor necrosis factor ( TNF)-alpha in the kidney were significantly reduced in IL-18R-deficient mice compared with those in control mice. On the other hand, serum anti-BSA Ab was not reduced in IL-18R-deficient mice. We conclude that the blockading of IL-18 signaling in BSA nephritis mice significantly alleviates immune complex renal disorder; this may thus represent a novel approach to the treatment of patients with immune complex nephritis.
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Authors | Masafumi Sugiyama, Koji Kinoshita, Kazuya Kishimoto, Hideki Shimazu, Yuji Nozaki, Shinya Ikoma, Masanori Funauchi |
Journal | Clinical immunology (Orlando, Fla.)
(Clin Immunol)
Vol. 128
Issue 1
Pg. 103-8
(Jul 2008)
ISSN: 1521-7035 [Electronic] United States |
PMID | 18462998
(Publication Type: Journal Article)
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Chemical References |
- Antigen-Antibody Complex
- RNA, Messenger
- Receptors, Interleukin-18
- Tumor Necrosis Factor-alpha
- Serum Albumin, Bovine
- Interferon-gamma
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Topics |
- Animals
- Antigen-Antibody Complex
- Glomerulonephritis
(chemically induced, metabolism, pathology)
- Immunohistochemistry
- Interferon-gamma
(biosynthesis)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Proteinuria
(chemically induced)
- RNA, Messenger
(analysis)
- Receptors, Interleukin-18
(deficiency, genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Serum Albumin, Bovine
(toxicity)
- Tumor Necrosis Factor-alpha
(biosynthesis)
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