[Two cases of pancreatic tumor with von Hippel-Lindau disease].
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| Abstract |
Von Hippel-Lindau disease (VHL disease) is an inherited neoplasia syndrome. VHL disease which frequently complicates pancreatic lesions is rarely diagnosed by existence of pancreatic involvements. We report two cases of VHL disease with pancreatic lesions. The first patient was a 40-year-old woman. Adrenal pheochromocytoma, spinal hemangioblastoma and pancreatic endocrine tumor were resected. The second case was a 68-year-old woman with past surgical histories included cerebellar and spinal hemangioblastoma. Subtotal pancreatectomy was performed for multiple serous cystadenoma. IPMN which has been never reported as pancreatic involvement of VHL disease were documented by imaging diagnosis in the first case, and by histological examination in the second case. We considered VHL disease from coexistent multiple tumors include pancreatic involvements and finally diagnosed by genetic examination in both cases. Care should be taken regarding the patient's right for treatment against for the genetic disease. We hold a genetic conference composed of multidisciplinary team. Consequently we detected another VHL disease patient from patient's family.
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| Authors | Hidenori Karasaki, Akira Ishizaki, Nobuyuki Yanagawa, Yasuhiro Nakano, Jyunpei Sasajima, Yusuke Mizukami, Satoshi Tanno, Yoshihiko Tokusashi, Naoyuki Miyokawa, Mitsuhiro Obara, Junichi Goto, Shuichi Kino, Toru Kono, Shinichi Kasai |
| Journal | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 105 Issue 5 Pg. 725-31 (May 2008) ISSN: 0446-6586 [Print] Japan |
| PMID | 18460863 (Publication Type: Case Reports, English Abstract, Journal Article) |
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