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Histone modifications: cycling with chromosomal replication.

Abstract
Histone modifications tend to be lost during chromosome duplication. Several recent studies suggest that the RNA interference pathway becomes active during the weakened transcriptional repression occurring at centromeres in S phase, resulting in the re-establishment of histone modifications that direct the formation of heterochromatin.
AuthorsGeneviève Thon
JournalCurrent biology : CB (Curr Biol) Vol. 18 Issue 9 Pg. R380-2 (May 06 2008) ISSN: 0960-9822 [Print] England
PMID18460317 (Publication Type: Journal Article, Comment)
Chemical References
  • Heterochromatin
  • Histones
Topics
  • DNA Replication (physiology)
  • Heterochromatin (metabolism)
  • Histones (metabolism)
  • RNA Interference (physiology)
  • S Phase (physiology)
  • Schizosaccharomyces

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