FTY720 (fingolimod) for relapsing multiple sclerosis.

Abstract

FTY720 (fingolimod) is a structural analogue of sphingosine, an endogenous lysophospholipid, which targets sphingosine-1-phosphate receptors after biotransformation to FTY720-phosphate. The immunomodulatory properties of this agent are mainly related to its ability to entrap lymphocytes in secondary lymphoid organs, reducing their availability for cell-mediated immune responses. Emerging evidence suggests that FTY720 also exerts direct actions on glial and precursor cells of the CNS which may be relevant for the process of tissue repair after injury. The therapeutic effects of the drug observed in animal models of human multiple sclerosis have provided the experimental basis for its clinical application. A recent Phase II study has demonstrated that oral FTY720 is effective in reducing disease activity in relapsing multiple sclerosis with a favorable adverse-effect profile. These results are awaiting confirmation in the three ongoing Phase III clinical trials evaluating FTY720 for relapsing-remitting multiple sclerosis.

• Authors: Alejandro Horga, Xavier Montalban
• Journal: Expert review of neurotherapeutics (Expert Rev Neurother) Vol. 8 Issue 5 Pg. 699-714 (May 2008) ISSN: 1744-8360 [Electronic] England
• PMID: 18457527 (Publication Type: Journal Article, Review)

Chemical References

• Immunosuppressive Agents
• Propylene Glycols
• Fingolimod Hydrochloride
• Sphingosine

Topics

• Clinical Trials, Phase III as Topic (trends)
• Fingolimod Hydrochloride
• Humans
• Immunosuppressive Agents (therapeutic use)
• Multiple Sclerosis, Relapsing-Remitting (drug therapy, immunology, prevention & control)
• Propylene Glycols (immunology, therapeutic use)
• Secondary Prevention
• Sphingosine (analogs & derivatives, immunology, therapeutic use)
• Treatment Outcome