Abstract | BACKGROUND AND PURPOSE: We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic inflammation components in this response. EXPERIMENTAL APPROACH: KEY RESULTS: CONCLUSIONS AND IMPLICATIONS:
Trypsin intradermal injection proved to be a reproducible model for the study of itching and the involvement of PAR-2 receptors. Also, trypsin-induced itching seems to be widely dependent on neurogenic inflammation, with a role for TRPV1 receptors. In addition, several other mediators located in the sensory nerves and skin also seem to contribute to this process.
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Authors | R Costa, D M Marotta, M N Manjavachi, E S Fernandes, J F Lima-Garcia, A F Paszcuk, N L M Quintão, L Juliano, S D Brain, J B Calixto |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 154
Issue 5
Pg. 1094-103
(Jul 2008)
ISSN: 0007-1188 [Print] England |
PMID | 18454165
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-((3-(1,3-benzodioxol-5-yl)-3-(((6-methoxy-2-naphthyl)sulfonyl)amino)propanoyl)amino)-3-(4-((2,6-dimethylpiperidinyl)methyl)phenyl)-N-isopropyl-N-methylpropanamide
- Anilides
- Antipruritics
- Bradykinin Receptor Antagonists
- Calcitonin Gene-Related Peptide Receptor Antagonists
- Cinnamates
- Cyclooxygenase 2 Inhibitors
- Dioxoles
- FR 173657
- N-(3-methoxyphenyl)-4-chlorocinnamanilide
- Oligopeptides
- Peptide Fragments
- Plant Proteins
- Pyrazoles
- Quinolines
- Receptor, PAR-2
- Receptors, Bradykinin
- Receptors, Calcitonin Gene-Related Peptide
- Sulfonamides
- TRPV Cation Channels
- TRPV1 protein, mouse
- protease inhibitor protein, Phaseolus lunatus
- calcitonin gene-related peptide (8-37)
- p-Methoxy-N-methylphenethylamine
- Ptgs2 protein, mouse
- Cyclooxygenase 2
- Trypsin
- Celecoxib
- Calcitonin Gene-Related Peptide
- Cromolyn Sodium
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Topics |
- Anilides
(pharmacology)
- Animals
- Antipruritics
(pharmacology)
- Behavior, Animal
(drug effects)
- Bradykinin Receptor Antagonists
- Calcitonin Gene-Related Peptide
(pharmacology)
- Calcitonin Gene-Related Peptide Receptor Antagonists
- Celecoxib
- Cell Degranulation
(drug effects)
- Cinnamates
(pharmacology)
- Cromolyn Sodium
(pharmacology)
- Cyclooxygenase 2
(metabolism)
- Cyclooxygenase 2 Inhibitors
(pharmacology)
- Dioxoles
(pharmacology)
- Disease Models, Animal
- Injections, Intradermal
- Male
- Mast Cells
(drug effects)
- Mice
- Mice, Knockout
- Nerve Fibers, Unmyelinated
(metabolism)
- Neurogenic Inflammation
(chemically induced, metabolism, prevention & control)
- Oligopeptides
(pharmacology)
- Peptide Fragments
(pharmacology)
- Plant Proteins
(pharmacology)
- Pruritus
(chemically induced, metabolism, prevention & control)
- Pyrazoles
(pharmacology)
- Quinolines
(pharmacology)
- Receptor, PAR-2
(antagonists & inhibitors, metabolism)
- Receptors, Bradykinin
(metabolism)
- Receptors, Calcitonin Gene-Related Peptide
(metabolism)
- Reproducibility of Results
- Signal Transduction
(drug effects)
- Sulfonamides
(pharmacology)
- TRPV Cation Channels
(antagonists & inhibitors, genetics, metabolism)
- Trypsin
(administration & dosage)
- p-Methoxy-N-methylphenethylamine
(pharmacology)
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