A simple and improved method for diagnosis of tuberculosis using hypertonic saline and sodium hydroxide to concentrate and decontaminate sputum.

Abstract	We report the use of hypertonic saline and sodium hydroxide (HS-SH) for concentration-decontamination of sputum samples for the diagnosis of tuberculosis. This method increases detection of mycobacteria in smears compared to examination of direct smears, is comparable and reduces contamination in cultures compared to NALC-NaOH.
Authors	Jessica N Ricaldi, Humberto Guerra
Journal	Tropical doctor (Trop Doct) Vol. 38 Issue 2 Pg. 97-9 (Apr 2008) ISSN: 0049-4755 [Print] England
PMID	18453499 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Saline Solution, Hypertonic Sodium Hydroxide
Topics	Bacteriological Techniques Decontamination (methods) Humans Mycobacterium tuberculosis (isolation & purification) Saline Solution, Hypertonic (pharmacology) Sodium Hydroxide (pharmacology) Specimen Handling (methods) Sputum (drug effects, microbiology) Tuberculosis, Pulmonary (diagnosis, microbiology)

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