Abstract | INTRODUCTION: CASE PRESENTATION: A 34-year-old male presented with cholestatic jaundice and severe pruritus after receiving oxycodone for analgesia post-T11 vertebrectomy. Extensive laboratory investigations and imaging studies did not reveal any other obvious cause for his jaundice and a liver biopsy confirmed canalicular cholestatis suggestive of drug-induced hepatotoxicity. The patient's symptoms and transaminases normalised on withdrawal of oxycodone confirming that oxycodone was the probable cause of the patient's hepatotoxicity. CONCLUSION: We conclude that cholestatic hepatitis is possibly a rare side effect of oxycodone use. Physicians should be aware of the possibility of this potentially serious picture of drug-induced hepatotoxicity.
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Authors | Vincent Ho, Maxwell Stewart, Peter Boyd |
Journal | Journal of medical case reports
(J Med Case Rep)
Vol. 2
Pg. 140
(May 01 2008)
ISSN: 1752-1947 [Print] England |
PMID | 18452597
(Publication Type: Journal Article)
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