Treatment of endometrial hyperplasia without atypia in peri- and postmenopausal women with a levonorgestrel intrauterine device.

Abstract

OBJECTIVE:

To assess the effectiveness of the Mirena levonorgestrel-releasing intrauterine system (LNG-IUS) in peri- and postmenopausal women with endometrial hyperplasia without atypia.

DESIGN:

All consecutive women with histologically documented endometrial hyperplasia without atypia recruited during a 1-year period participated in an open, prospective, single-center study. They were followed for at least 2 years after levonorgestrel-releasing intrauterine system insertion. The pattern of uterine bleeding was evaluated on a 4-point qualitative scale (1 = amenorrhea, 2 = scarce, 3 = normal, 4 = abundant).

RESULTS:

The study population consisted of 15 women with a mean (SD) age of 49 (2.7) years. Compared with baseline, bleeding decreased quantitatively from a mean score of 3 at baseline (normal bleeding) to 2 (scarce) at 3and 6 months, and 1 (amenorrhea) at 24 months. Endometrial biopsies performed at 12 months revealed atrophicendometrium in 14 women (93.3%) and secretory endometrium in 1 (6.7%) (P < 0.001). At 24 months, endometrial atrophy was documented in 100% of women.

CONCLUSIONS:

The levonorgestrel-releasing intrauterine system seems to be an effective and safe alternative in the treatment of peri- and postmenopausal women with (simple) endometrial hyperplasia without atypia.

• Authors: Sergio Haimovich, Miguel A Checa, Gemma Mancebo, Pere Fusté, Ramón Carreras
• Journal: Menopause (New York, N.Y.) (Menopause) 2008 Sep-Oct Vol. 15 Issue 5 Pg. 1002-4 ISSN: 1530-0374 [Electronic] United States
• PMID: 18451744 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Contraceptive Agents, Female
• Levonorgestrel

Topics

• Adult
• Contraceptive Agents, Female (therapeutic use)
• Endometrial Hyperplasia (drug therapy)
• Endometrium (drug effects)
• Female
• Follow-Up Studies
• Humans
• Intrauterine Devices, Medicated
• Levonorgestrel (therapeutic use)
• Menstruation (drug effects)
• Middle Aged
• Perimenopause
• Postmenopause
• Prospective Studies
• Spain
• Treatment Outcome