Abstract |
Two new bicyclic hexapeptides, RA-XXIII and RA-XXIV, were isolated from the roots of Rubia cordifolia L. (Rubiaceae). Their structures were determined by the analysis of their 2D NMR spectra, chemical methods, and X-ray crystallography. The IC50 values of RA-XXIII and RA-XXIV against P-388 leukemia cells were 0.16 and 0.48 microg/ml, respectively.
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Authors | Ji-Ean Lee, Yukio Hitotsuyanagi, Haruhiko Fukaya, Kazuyuki Kondo, Koichi Takeya |
Journal | Chemical & pharmaceutical bulletin
(Chem Pharm Bull (Tokyo))
Vol. 56
Issue 5
Pg. 730-3
(May 2008)
ISSN: 0009-2363 [Print] Japan |
PMID | 18451569
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Peptides, Cyclic
- RA-XXIII
- RA-XXIV
- Ammonia
- Bromine
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Topics |
- Ammonia
(chemistry)
- Antineoplastic Agents, Phytogenic
(isolation & purification, pharmacology)
- Bromine
(chemistry)
- Crystallography, X-Ray
- Magnetic Resonance Spectroscopy
- Methylation
- Peptides, Cyclic
(isolation & purification, pharmacology)
- Plant Roots
(chemistry)
- Rubia
(chemistry)
- Spectrometry, Mass, Electrospray Ionization
- Spectrophotometry, Infrared
- Spectrophotometry, Ultraviolet
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