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New cytotoxic bicyclic hexapeptides, RA-XXIII and RA-XXIV, from Rubia cordifolia L.

Abstract
Two new bicyclic hexapeptides, RA-XXIII and RA-XXIV, were isolated from the roots of Rubia cordifolia L. (Rubiaceae). Their structures were determined by the analysis of their 2D NMR spectra, chemical methods, and X-ray crystallography. The IC50 values of RA-XXIII and RA-XXIV against P-388 leukemia cells were 0.16 and 0.48 microg/ml, respectively.
AuthorsJi-Ean Lee, Yukio Hitotsuyanagi, Haruhiko Fukaya, Kazuyuki Kondo, Koichi Takeya
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 56 Issue 5 Pg. 730-3 (May 2008) ISSN: 0009-2363 [Print] Japan
PMID18451569 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Peptides, Cyclic
  • RA-XXIII
  • RA-XXIV
  • Ammonia
  • Bromine
Topics
  • Ammonia (chemistry)
  • Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
  • Bromine (chemistry)
  • Crystallography, X-Ray
  • Magnetic Resonance Spectroscopy
  • Methylation
  • Peptides, Cyclic (isolation & purification, pharmacology)
  • Plant Roots (chemistry)
  • Rubia (chemistry)
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

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