Abstract | BACKGROUND AND AIMS: We have developed a novel tumor-ablation device for liver tumors utilizing heat energy induced by magnesium ferrite (MgFe(2)O(4)) particles under an alternating magnetic field (AMF) produced by electric currents. This novel device can repeatedly heat liver tumors at lower temperature than usual heating devices, such as radiofrequency ablation therapy, with slight infliction of pain. This study assesses its heating effect on rat liver tumors as local therapy. METHOD: RESULTS: The mean temperature of the heated tumors was 60.2 +/- 1.8 degrees C. The tumor cells were constricted, and chromatin of nuclei had shrunk immediately after heating. The heat-injury area that contained the tumors was negative for NADH diaphorase activity. After 3 days, the tumor cells in the heat-injury area became positive for TUNEL staining, which detects cell death. At 7 days, the mean tumor diameters were significantly smaller in the heating group than in the control group (6.15 +/- 0.47 mm vs 16.89 +/- 2.69 mm; P < 0.05). CONCLUSION:
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Authors | Koichi Sato, Yuji Watanabe, Atsushi Horiuchi, Shungo Yukumi, Takashi Doi, Motohira Yoshida, Yuji Yamamoto, Tsunehiro Maehara, Takashi Naohara, Kanji Kawachi |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 23
Issue 7 Pt 1
Pg. 1105-11
(Jul 2008)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 18444992
(Publication Type: Journal Article)
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Chemical References |
- Ferric Compounds
- Magnesium Compounds
- magnesium ferrite
- Dihydrolipoamide Dehydrogenase
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Topics |
- Animals
- Apoptosis
- Cell Line, Tumor
- Dihydrolipoamide Dehydrogenase
(metabolism)
- Equipment Design
- Ferric Compounds
(chemistry)
- Hyperthermia, Induced
(instrumentation)
- In Situ Nick-End Labeling
- Liver Neoplasms, Experimental
(enzymology, pathology, therapy)
- Magnesium Compounds
(chemistry)
- Magnetics
(instrumentation)
- Male
- Needles
- Rats
- Staining and Labeling
(methods)
- Time Factors
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