[Combined intravitreal triamcinolone and photodynamic therapy for retinal angiomatous proliferation after photodynamic therapy].

Abstract

PURPOSE:

To investigate the 1-year results of treatment for retinal angiomatous proliferation (RAP), especially focused on the combination therapy of intravitreal injection of tiamcinolone acetonide with photodynamic therapy (IVTA-PDT).

METHODS:

Between July 2004 and July 2005, IVTA-PDT was performed in 7 patients (9 eyes) with RAP at the Ohtsuka Eye Hospital. We reviewed the records of 4 of these patients (5 eyes) who had received IVTA-PDT during follow-up.

RESULTS:

PDT was effective in only 1 of the 9 eyes. During IVTA-PDT, leakage from neovascularization was observed on angiography, and retinal edema and retinal pigment epithelial detachment (RPED) were observed on optical coherence tomography (OCT), even though PDT had been performed several times in all 5 eyes receiving IVTA-PDT. Complete resolution of angiographic leakage and improvement of retinal edema and RPED were observed at the examination 3 months after IVTA-PDT. At 1 year after IVTA-PDT, the fundus findings remained stable in 4 eyes, but angiographic leakage and RPED had progressed slightly in one eye. Visual acuity 1 year after IVTA had decreased compared with that at the primary PDT, but was almost the same as that at the beginning of IVTA-PDT.

CONCLUSIONS:

IVTA-PDT for eyes with RAP, in which PDT had been performed several times, may be effective for improvement or elimination of retinal edema, achieving rapid regression of neovascularization, and stabilizing visual acuity.

• Authors: Taiichi Hikichi, Hideo Ohtsuka, Makoto Higuchi, Takuro Matsushita, Hiroko Ariga, Shoko Kosaka, Reiko Matsushita
• Journal: Nippon Ganka Gakkai zasshi (Nippon Ganka Gakkai Zasshi) Vol. 112 Issue 4 Pg. 361-70 (Apr 2008) ISSN: 0029-0203 [Print] Japan
• PMID: 18444415 (Publication Type: English Abstract, Journal Article)

Chemical References

• Triamcinolone

Topics

• Aged
• Aged, 80 and over
• Combined Modality Therapy
• Female
• Humans
• Injections
• Male
• Photochemotherapy
• Retinal Neovascularization (therapy)
• Treatment Outcome
• Triamcinolone (administration & dosage)
• Vitreous Body