Efficacy of cefditoren in the treatment of upper respiratory tract infections: a pooled analysis of six clinical trials.

Abstract

OBJECTIVE:

A pooled analysis of all upper respiratory tract infection studies performed with cefditoren (CDN) was performed.

METHODS:

Studies were prospective, comparative, multicentre and randomised. Comparators were penicillin V (pharyngitis) and cefuroxime or amoxicillin/clavulanate (sinusitis). A total of 1,322 patients were randomized, 1,241 included in intention-to-treat (ITT) and 1,010 in per-protocol populations (PP) in pharyngotonsillitis studies, and 1,819 randomized, 1,726 included in ITT and 1,589 in PP in acute sinusitis studies.

RESULTS:

No significant differences in pharyngitis clinical response were found (success rates: 89.4 % to 95.3 %). S. pyogenes eradication was higher with cefditoren at end of therapy (EOT) (90.4% vs. 82.7%; p=0.002) and follow-up (84.7% vs. 76.7%; p=0.008), although no statistically significant (p<0.001). In both groups, clinical failures were significantly higher (p<0.001) in patients showing S. pyogenes persistence than in those showing eradication (> or =98.5% vs. 51.4 %). No differences in sinusitis clinical response were found between CDN and comparators both at EOT (80.2% vs. 84.8%) and at end of follow-up (71.2% vs. 77.4%).

CONCLUSION:

Cefditoren had similar point estimates of clinical efficacy to comparators in pharyngotonsillitis and sinusitis, and a tendency to higher S. pyogenes eradication in pharyngotonsillitis.

• Authors: J J Granizo, M J Giménez, J Barberán, P Coronel, M Gimeno, L Aguilar
• Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia (Rev Esp Quimioter) Vol. 21 Issue 1 Pg. 14-21 (Mar 2008) ISSN: 0214-3429 [Print] Spain
• PMID: 18443928 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• cefditoren

Topics

• Anti-Bacterial Agents (therapeutic use)
• Cephalosporins (therapeutic use)
• Humans
• Randomized Controlled Trials as Topic
• Respiratory Tract Infections (drug therapy)
• Treatment Outcome