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Successful treatment with plasma exchange in adult-onset Still's disease with hyper-IL-18-naemia and hyperallergic state.

Abstract
Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his disease activity. Drug lymphocyte stimulation tests were positive for three drugs in the patient. Hypercytokinaemia was controlled by plasma exchange therapy.
AuthorsTomoki Ito, Yoshio Ozaki, Keiko Shimamoto, Hideki Amuro, Tsutomu Tanijiri, Takashi Yokoi, Yonsu Son, Kenichirou Tajima, Shirou Fukuhara
JournalModern rheumatology (Mod Rheumatol) Vol. 18 Issue 4 Pg. 407-10 ( 2008) ISSN: 1439-7595 [Print] England
PMID18443740 (Publication Type: Case Reports, Journal Article)
Chemical References
  • IL6 protein, human
  • Interleukin-18
  • Interleukin-6
  • Interferon-gamma
Topics
  • Adult
  • Drug Hypersensitivity (complications, therapy)
  • Humans
  • Interferon-gamma (blood)
  • Interleukin-18 (blood)
  • Interleukin-6 (blood)
  • Male
  • Plasma Exchange
  • Still's Disease, Adult-Onset (complications, therapy)

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