Neither serum ferritin nor the number of red blood cell transfusions affect overall survival in refractory anemia with ringed sideroblasts.

Abstract

In a retrospective study of 126 adult patients with French-American-British-defined refractory anemia with ringed sideroblasts (RARS), staging by the International Prognostic Scoring System was highly predictive of survival outcome (P < 0.0001). In addition, red blood cell (RBC) transfusion requirement at diagnosis (P = 0.001), but not the number of RBC units transfused during the disease course (P = 0.17), was independently associated with inferior survival. There were no correlations between survival and serum ferritin level, measured either at diagnosis (median 567 ng/mL, range 16-3,475; P = 0.24) or during follow-up (median 1,108 ng/mL; range 238-43,500; P = 0.72). Similarly, there was no difference in survival when patients were stratified by serum ferritin levels of < or > or =1,000 ng/mL at diagnosis or peak serum ferritin levels of <1,000, 1,000-5,000, or >5,000 ng/mL during follow-up. The current study does not support the contention that transfusional hemosiderosis is an adverse prognostic factor in "good risk" myelodysplastic syndrome.

• Authors: Cheng E Chee, David P Steensma, Wenting Wu, Curtis A Hanson, Ayalew Tefferi
• Journal: American journal of hematology (Am J Hematol) Vol. 83 Issue 8 Pg. 611-3 (Aug 2008) ISSN: 1096-8652 [Electronic] United States
• PMID: 18442062 (Publication Type: Journal Article)
• Copyright: Copyright 2008 Wiley-Liss, Inc.

Chemical References

• Ferritins

Topics

• Adult
• Aged
• Aged, 80 and over
• Anemia, Sideroblastic (diagnosis, mortality)
• Cause of Death
• Erythrocyte Transfusion
• Female
• Ferritins (blood)
• Humans
• Male
• Middle Aged
• Prognosis
• Retrospective Studies
• Survival Analysis
• Survival Rate