| Abstract | OBJECTIVE: The objective of this study was to improve the treatment results for locally advanced tongue cancer. A combination of radiotherapy with continuous intra-arterial therapy using CBDCA was used. STUDY DESIGN: According to TNM staging (1997), 29 patients had stage III lesions and 11 patients had stage IV (M0) lesions. A catheter was inserted through the lingual artery in 26 patients, through the external carotid artery in 11 patients, and through the faciolingual trunk in 2 patients. CBDCA was continuously infused for 4 to 6 weeks. With IA chemotherapy, external irradiation (median dose: 46.8 Gy) was simultaneously performed, and 1 to 2 courses of systemic chemotherapy were performed in 19 patients before intra-arterial chemotherapy. RESULTS: The 5-year local control rate was 65%. The 5-year OS rate was 39.5%. There were no clinically significant adverse side effects. CONCLUSION: Continuous IA CBDCA and concurrent radiation therapy can be delivered safely with good efficacy for locally advanced carcinoma of the tongue. |
| Authors | Nobukazu Fuwa, Takeshi Kodaira, Kazuhisa Furutani, Hiroyuki Tachibana, Tatsuya Nakamura
(Affiliation: Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Japan. nfuwa at aichi-cc.jp)
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| Journal | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
(Oral Surg Oral Med Oral Pathol Oral Radiol Endod)
Vol. 105
Issue 6
Pg. 714-9
(Jun 2008)
ISSN: 1528-395X United States |
| PMID | 18439857
(Publication Type: Journal Article)
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| Chemical References |
- Organoplatinum Compounds
- Carboplatin
- Fluorouracil
- nedaplatin
|
| Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carboplatin
(administration & dosage, toxicity)
- Carcinoma, Squamous Cell
(drug therapy, pathology, radiotherapy)
- Carotid Artery, External
- Drug Administration Schedule
- Female
- Fluorouracil
(administration & dosage, toxicity)
- Humans
- Infusions, Intra-Arterial
- Injections, Intravenous
- Kaplan-Meiers Estimate
- Male
- Middle Aged
- Neoplasm Staging
- Organoplatinum Compounds
(administration & dosage, toxicity)
- Radiotherapy Dosage
- Radiotherapy, Adjuvant
- Retrospective Studies
- Tongue
(blood supply)
- Tongue Neoplasms
(drug therapy, pathology, radiotherapy)
|
