Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
Abstract | BACKGROUND & AIMS: METHODS: RESULTS:
Cisplatin, 5-HT, BW723C86 (5-HT2B-receptor agonist), and m-chlorophenylpiperazine HCl (5-HT2C agonist) markedly decreased plasma acylated- ghrelin levels, although 5-HT3 and 5-HT4 agonists had no effect. In contrast, 5-HT2B and 5-HT2C antagonists suppressed the cisplatin-induced decrease of plasma acylated- ghrelin level and food intake. Administration of rat ghrelin improved the cisplatin-induced decrease in food intake. Vagotomy decreased the plasma acylated- ghrelin level, which was decreased further by cisplatin. Rikkunshito suppressed such cisplatin-induced decreases of plasma acylated- ghrelin level and food intake. The suppressive effect of rikkunshito was blocked by a ghrelin antagonist. Components of rikkunshito, 3,3',4',5,6,7,8-heptamethoxyflavone, hesperidin, and iso- liquiritigenin showed a 5-HT2B-antagonistic effect in vitro, and oral administration of rikkunshito suppressed the cisplatin-induced decrease in the plasma acylated- ghrelin level. CONCLUSIONS:
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Authors | Hiroshi Takeda, Chiharu Sadakane, Tomohisa Hattori, Takehiko Katsurada, Tatsuya Ohkawara, Koichi Nagai, Masahiro Asaka |
Journal | Gastroenterology
(Gastroenterology)
Vol. 134
Issue 7
Pg. 2004-13
(Jun 2008)
ISSN: 1528-0012 [Electronic] United States |
PMID | 18439428
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 1-(5-(2-thenyloxy)-1H-indol-3-yl)propan-2-amine
- 5,6,2',3',5',6'-hexamethoxyflavone
- 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline
- Aminopyridines
- Antineoplastic Agents
- Chalcones
- Dopamine Antagonists
- Drugs, Chinese Herbal
- Flavones
- GHRP-6, Lys(3)-
- Gastrointestinal Agents
- Ghrelin
- Indoles
- Oligopeptides
- Piperazines
- Quinolines
- Receptor, Serotonin, 5-HT2B
- Receptor, Serotonin, 5-HT2C
- Receptors, Ghrelin
- SB 215505
- Serotonin 5-HT2 Receptor Antagonists
- Serotonin Receptor Agonists
- Thiophenes
- liu-jun-zi-tang
- Serotonin
- isoliquiritigenin
- Hesperidin
- Cisplatin
- 1-(3-chlorophenyl)piperazine
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Topics |
- Acylation
- Aminopyridines
(pharmacology)
- Animals
- Anorexia
(chemically induced, metabolism, physiopathology, prevention & control)
- Antineoplastic Agents
- Body Weight
(drug effects)
- Chalcones
(pharmacology)
- Cisplatin
- Disease Models, Animal
- Dopamine Antagonists
(metabolism, pharmacology, therapeutic use)
- Dose-Response Relationship, Drug
- Drugs, Chinese Herbal
(metabolism, pharmacology, therapeutic use)
- Eating
(drug effects)
- Flavones
(pharmacology)
- Gastric Mucosa
(metabolism)
- Gastrointestinal Agents
(metabolism, pharmacology, therapeutic use)
- Ghrelin
(blood, metabolism)
- Hesperidin
(pharmacology)
- Indoles
(pharmacology)
- Male
- Oligopeptides
(pharmacology)
- Piperazines
(pharmacology)
- Protein Binding
- Quinolines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptor, Serotonin, 5-HT2B
(metabolism)
- Receptor, Serotonin, 5-HT2C
(metabolism)
- Receptors, Ghrelin
(drug effects, metabolism)
- Serotonin
(metabolism)
- Serotonin 5-HT2 Receptor Antagonists
- Serotonin Receptor Agonists
(pharmacology)
- Stomach
(drug effects, innervation)
- Thiophenes
(pharmacology)
- Vagotomy
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