[A patient with very high serum level of human chorionic gonadotrophin; the diagnosis is not always a germ-cell tumour].

A 47-year-old man, who presented with dyspnoea, gynaecomasty, and aphasia due to an extensively metastasized malignancy, was transferred to the hospital for chemotherapy as a matter of urgency. Because of his severe clinical symptoms, the widespread presence of metastases on radiological examination, and a striking increase in serum human chorionic gonadotrophin (HCG), the patient was treated with bleomycin, etoposide, and cisplatin (BEP) for a suspected metastasized germ-cell tumour. Definitive histology, however, revealed not a germ-cell tumour, but instead a large-cell undifferentiated HCG-producing carcinoma of uncertain primary origin. Using this patient's history, ectopic HCG production by malignancies is described in more detail.
AuthorsH J J van der Vliet, P Lefesvre, C J van Groeningen
JournalNederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 152 Issue 12 Pg. 705-9 (Mar 22 2008) ISSN: 0028-2162 [Print] Netherlands
Vernacular TitleEen patiënt met een sterk verhoogde serumwaarde van humaan choriongonadotrofine; de diagnose is niet altijd een kiemceltumor.
PMID18438068 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Chorionic Gonadotropin
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
  • Carcinoma, Large Cell (diagnosis, drug therapy, metabolism, pathology)
  • Chorionic Gonadotropin (blood)
  • Diagnosis, Differential
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasm Metastasis (diagnosis, drug therapy, pathology)

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