GLP-1: physiological effects and potential therapeutic applications.

Abstract

Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone with the potential to change diabetes. The physiological effects of GLP-1 are multiple, and many seem to ameliorate the different conditions defining the diverse physiopathology seen in type 2 diabetes. In animal studies, GLP-1 stimulates beta-cell proliferation and neogenesis and inhibits beta-cell apoptosis. In humans, GLP-1 stimulates insulin secretion and inhibits glucagon and gastrointestinal secretions and motility. It enhances satiety and reduces food intake and has beneficial effects on cardiovascular function and endothelial dysfunction. Enhancing incretin action for therapeutic use includes GLP-1 receptor agonists resistant to degradation (incretin mimetics) and dipeptidyl peptidase (DPP)-4 inhibitors. In clinical trials with type 2 diabetic patients on various oral antidiabetic regimes, both treatment modalities efficaciously improve glycaemic control and beta-cell function. Whereas the incretin mimetics induce weight loss, the DPP-4 inhibitors are considered weight neutral. In type 1 diabetes, treatment with GLP-1 shows promising effects. However, several areas need clinical confirmation: the durability of the weight loss, the ability to preserve functional beta-cell mass and the applicability in other than type 2 diabetes. As such, long-term studies and studies with cardiovascular end-points are needed to confirm the true benefits of these new classes of antidiabetic drugs in the treatment of diabetes mellitus.

• Authors: Kasper Aaboe, Thure Krarup, Sten Madsbad, Jens Juul Holst
• Journal: Diabetes, obesity & metabolism (Diabetes Obes Metab) Vol. 10 Issue 11 Pg. 994-1003 (Nov 2008) ISSN: 1463-1326 [Electronic] England
• PMID: 18435775 (Publication Type: Journal Article, Review)

Chemical References

• Dipeptidyl-Peptidase IV Inhibitors
• GLP1R protein, human
• Glucagon-Like Peptide-1 Receptor
• Hypoglycemic Agents
• Receptors, Glucagon
• Glucagon-Like Peptide 1
• Glucagon

Topics

• Animals
• Diabetes Mellitus, Type 2 (drug therapy, metabolism)
• Dipeptidyl-Peptidase IV Inhibitors (therapeutic use)
• Glucagon (metabolism)
• Glucagon-Like Peptide 1 (physiology, therapeutic use)
• Glucagon-Like Peptide-1 Receptor
• Humans
• Hypoglycemic Agents (therapeutic use)
• Islets of Langerhans (drug effects, metabolism)
• Receptors, Glucagon (antagonists & inhibitors)
• Satiety Response (drug effects)
• Weight Loss