Abstract | INTRODUCTION: Bcl-2 antanogene-1 (Bag-1) binds the anti-apoptotic mediator Bcl-2, and enhances its activity. Bcl-2 and Bag-1 are associated with chemotherapy resistance in cancer cells. Drugs that target Bcl-2 are currently in clinical development. The purpose of the present study was to examine expression patterns of Bag-1 in a large cohort of breast tumors and to assess the association with Bcl-2, estrogen receptor, progesterone receptor and Her2/neu, and other clinical/pathological variables. METHODS: RESULTS: High Bcl-2 expression was associated with improved survival in the entire cohort and in the node-positive subset (P = 0.008 and P = 0.002, respectively). High Bag-1 expression was associated with improved survival in the node-positive subset (P = 0.006). On multivariable analysis, neither Bcl-2 nor Bag-1 retained their independence as prognostic markers. Strong associations were found between Bag-1, Bcl-2, estrogen receptor and progesterone receptor. CONCLUSION: Bag-1 and Bcl-2 expression in breast tumors is associated with improved outcome and steroid receptor positivity. Evaluation of Bcl-2 and Bag-1 expression in breast cancer may identify a subset of patients with a favorable prognosis, who might not benefit from chemotherapy or who might benefit from Bcl-2 targeting agents in addition to antihormonal therapy.
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Authors | Yasmine Nadler, Robert L Camp, Jennifer M Giltnane, Christopher Moeder, David L Rimm, Harriet M Kluger, Yuval Kluger |
Journal | Breast cancer research : BCR
(Breast Cancer Res)
Vol. 10
Issue 2
Pg. R35
( 2008)
ISSN: 1465-542X [Electronic] England |
PMID | 18430249
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- BCL2-associated athanogene 1 protein
- Biomarkers, Tumor
- DNA-Binding Proteins
- Proto-Oncogene Proteins c-bcl-2
- Receptors, Estrogen
- Receptors, Progesterone
- Transcription Factors
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Topics |
- Adult
- Aged
- Antineoplastic Agents
(therapeutic use)
- Biomarkers, Tumor
(analysis)
- Breast Neoplasms
(chemistry, drug therapy, pathology)
- DNA-Binding Proteins
(analysis)
- Drug Resistance, Neoplasm
- Female
- Fluorescent Antibody Technique
- Follow-Up Studies
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Lymphatic Metastasis
- Middle Aged
- Predictive Value of Tests
- Prognosis
- Proportional Hazards Models
- Protein Array Analysis
- Proto-Oncogene Proteins c-bcl-2
(analysis)
- Receptors, Estrogen
(analysis)
- Receptors, Progesterone
(analysis)
- Transcription Factors
(analysis)
- Treatment Outcome
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