Abstract |
Lichen sclerosus is an uncommon, chronic inflammatory skin disorder of unknown origin. It is clinically characterized by sclerotic, whitish, atrophic-type lesions. The most frequent site of the lesions is generally the genital region, with about 15-20% having additional extragenital involvement. We present the case of a 62-year-old woman with a very extensive extragenital lichen sclerosus who showed great clinical and subjective improvement with 0.1% tacrolimus ointment and psoralen plus UVA (PUVA), without any topical or systemic adverse effects. Combined treatment of 0.1% tacrolimus ointment and PUVA may be a good option in extensive cases of lichen sclerosus or when other treatment options have failed, and has a good tolerability and safety profile.
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Authors | Marta Valdivielso-Ramos, Celso Bueno, José Manuel Hernanz |
Journal | American journal of clinical dermatology
(Am J Clin Dermatol)
Vol. 9
Issue 3
Pg. 175-9
( 2008)
ISSN: 1175-0561 [Print] New Zealand |
PMID | 18429647
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Ointments
- Tacrolimus
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Topics |
- Drug Therapy, Combination
- Female
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Lichen Sclerosus et Atrophicus
(drug therapy)
- Middle Aged
- Ointments
- PUVA Therapy
- Tacrolimus
(administration & dosage, therapeutic use)
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