[Assessment of berlition effectiveness in ischemic stroke with CT perfusion imaging of the brain].

Abstract

Berlition, an alpha-lipoic acid preparation, is a natural regulator of the free-radical processes. It was used as an add-on therapy in the management of patients in the acute period of ischemic stroke during 10 days. A main group included 15 patients treated with berlition and a comparison group - 11 patients who received a basic therapy. Patients' age was 30-60 years. A complete clinical study of patients was conducted during 21 days of treatment. CT perfusion imaging of the brain with contrast material was carried out on 1st, 5th and 15th days. The higher therapeutic effectiveness was found in the main group of patients, with complete functional rehabilitation in 33% of cases and significant regress of neurologic symptoms in 67%. These changes were correlated with positive shifts of different hemodynamic parameters to the 15th day of treatment.

• Authors: G R Iksanova, E I Saĭfullina, E M Kolchina, L B Novikova
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 108 Issue 1 Pg. 45-50 ( 2008) ISSN: 1997-7298 [Print] Russia (Federation)
• PMID: 18427519 (Publication Type: Journal Article)

Chemical References

• Thioctic Acid

Topics

• Adult
• Brain (blood supply)
• Brain Ischemia (diagnostic imaging, drug therapy)
• Cerebrovascular Circulation
• Female
• Humans
• Male
• Middle Aged
• Thioctic Acid (analogs & derivatives, therapeutic use)
• Tomography, X-Ray Computed