| Abstract | Assessment of 1177 human immunodeficiency virus (HIV) resistance genotypes at an HIV/AIDS clinic showed a decrease in the incidence of the K65R mutation, from 15.2% of isolates during the period 2002-2004 to 2.7% of isolates during the period 2005-2006 (P < .001), despite elevated and stable rates of tenofovir use. A reduction in the rate of coadministration of didanosine (from 41.6% of patients in 2004 to 0.8% of patients in 2006; P < .001) largely explained this observation. |
| Authors | Carmen de Mendoza, Inmaculada Jiménez-Nacher, Carolina Garrido, Pablo Barreiro, Eva Poveda, Angélica Corral, Natalia Zahonero, Juan González-Lahoz, Vincent Soriano
(Affiliation: Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain. cmendoza at teleline.es)
|
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 46
Issue 11
Pg. 1782-5
(Jun 1 2008)
ISSN: 1537-6591 United States |
| PMID | 18426370
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-HIV Agents
- Phosphonic Acids
- Reverse Transcriptase Inhibitors
- tenofovir
- Didanosine
- Adenine
- HIV Reverse Transcriptase
|
| Topics |
- Adenine
(analogs & derivatives, pharmacology)
- Anti-HIV Agents
(pharmacology)
- Didanosine
(pharmacology)
- Drug Resistance, Multiple, Viral
(genetics)
- HIV Infections
(metabolism)
- HIV Reverse Transcriptase
(antagonists & inhibitors, genetics)
- HIV-1
(drug effects, enzymology, genetics)
- Humans
- Mutation
- Phosphonic Acids
(pharmacology)
- Retrospective Studies
- Reverse Transcriptase Inhibitors
(pharmacology)
|
