Abstract | BACKGROUND: OBJECTIVES: SEARCH STRATEGY: The MEDLINE, PUBMED and EMBASE databases were searched using the search criteria " microscopic colitis" or " lymphocytic colitis" and "treatment" or " therapy" or "management" to identify relevant papers published between 1970 and December 2007. Manual searches from the references of identified papers and relevant review papers were performed. Abstracts from major gastroenterological meetings were searched to identify research submitted in abstract form only. The trial registry website www.ClinicalTrials.gov was searched to identify registered but unpublished trials. Finally, the Cochrane Central Register of Controlled Trials and the Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders Group Specialized Trials Register were searched for other studies. SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: Data were extracted independently by each author onto 2x2 tables (treatment versus placebo or active comparator and response versus no response). For therapies assessed in one trial only, P values were derived using the chi-square test. MAIN RESULTS: Forty-one patients were enrolled in the trial studying budesonide (9 mg/day for 6 weeks versus placebo). Budesonide was more effective than placebo at inducing both clinical (P = 0.004; NNT = 3) and histological responses (P = 0.04; NNT = 3). Forty-one patients were enrolled in the study assessing mesalazine versus mesalazine plus cholestyramine. A high proportion of patients in each group responded to treatment. However, no statistically significant difference in clinical response was found between the two treatment groups (P = 0.95). Five patients were enrolled in the trial studying bismuth subsalicylate (nine 262 mg tablets daily for 8 weeks vs. placebo). There were no differences in clinical (P=0.10) or histological responses (P=0.71) in patients treated with bismuth subsalicylate compared with placebo. AUTHORS' CONCLUSIONS:
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Authors | N Chande, J W D McDonald, J K Macdonald |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 2
Pg. CD006096
(Apr 16 2008)
ISSN: 1469-493X [Electronic] England |
PMID | 18425936
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Antidiarrheals
- Organometallic Compounds
- Salicylates
- Cholestyramine Resin
- Mesalamine
- Budesonide
- bismuth subsalicylate
- Bismuth
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Topics |
- Antidiarrheals
(therapeutic use)
- Bismuth
(therapeutic use)
- Budesonide
(therapeutic use)
- Cholestyramine Resin
(therapeutic use)
- Colitis, Lymphocytic
(drug therapy)
- Humans
- Mesalamine
(therapeutic use)
- Organometallic Compounds
(therapeutic use)
- Randomized Controlled Trials as Topic
- Salicylates
(therapeutic use)
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