Clobazam as an add-on in the management of refractory epilepsy.

Abstract

BACKGROUND:

Epilepsy effects approximately 1% of the population, with up to 30% of patients continuing to have seizures despite antiepileptic drug treatment.

OBJECTIVES:

To assess the efficacy and tolerability of clobazam when used as an add-on therapy for patients with refractory partial onset or generalised onset seizures.

SEARCH STRATEGY:

We searched the following on 22nd March 2007: (a) The Cochrane Epilepsy Group Specialised Register; (b) The Cochrane Central Register of Controlled Trials (CENTRAL); (c) MEDLINE; (d) EMBASE; (e) Database of Abstracts of Reviews of Effectiveness (DARE); (f) American College of Physicians Journals; (g) BIOSIS.

SELECTION CRITERIA:

Randomised trials of add-on clobazam, with adequate methods of allocation concealment, recruiting patients with drug refractory partial or generalised onset seizures, with a minimum treatment period of eight weeks.

DATA COLLECTION AND ANALYSIS:

Two review authors independently selected trials for inclusion and extracted relevant data. The following outcomes were assessed: 50% or greater reduction in seizures; seizure freedom; treatment withdrawal and adverse effects.

MAIN RESULTS:

Four cross-over studies, representing 196 participants, were included. However, due to significant methodological heterogeneity and differences in outcome measures it was not possible to summarise data in a meta-analysis. Only two of the studies reported a 50% or greater seizure reduction compared to placebo; 57.7% and 52.4%. Side effects were only described in two of the studies, reportedly present in 36% and 85% of patients.

AUTHORS' CONCLUSIONS:

Clobazam as an add-on treatment may reduce seizure frequency and may be most effective in partial onset seizures. However, it is not clear who will best benefit and over what time-frame. A large scale, randomised controlled trial conducted over a greater period of time, incorporating subgroups with differing seizure types, is required to inform clinical practice.

• Authors: B Michael, A G Marson
• Journal: The Cochrane database of systematic reviews (Cochrane Database Syst Rev) Issue 2 Pg. CD004154 (Apr 16 2008) ISSN: 1469-493X [Electronic] England
• PMID: 18425899 (Publication Type: Journal Article, Review, Systematic Review)

Chemical References

• Anticonvulsants
• Benzodiazepines
• Clobazam

Topics

• Anticonvulsants (administration & dosage, therapeutic use)
• Benzodiazepines (administration & dosage, therapeutic use)
• Clobazam
• Epilepsy (drug therapy)
• Humans
• Randomized Controlled Trials as Topic