Plasma exchange in a case of severe factor X deficiency in pregnancy: critical review of the literature.

Abstract

Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.

• Authors: Giuseppe Chiossi, Joel A Spero, Emmanuel J Esaka, Kristin Novic, Jennifer U Celebrezze, Steven H Golde, Ronald L Thomas
• Journal: American journal of perinatology (Am J Perinatol) Vol. 25 Issue 3 Pg. 189-92 (Mar 2008) ISSN: 0735-1631 [Print] United States
• PMID: 18425721 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Breech Presentation (surgery)
• Cesarean Section
• Factor X Deficiency (therapy)
• Female
• Humans
• Plasma Exchange
• Postpartum Hemorrhage (prevention & control)
• Pregnancy
• Pregnancy Complications, Hematologic (therapy)