The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C.

Abstract

Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC(50) values of 0.68 and 4.28microg/ml, respectively.

• Authors: Rohan A Davis, James Longden, Vicky M Avery, Peter C Healy
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 9 Pg. 2836-9 (May 01 2008) ISSN: 1464-3405 [Electronic] England
• PMID: 18424045 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Dipeptides
• Diterpenes
• trichodermamide C

Topics

• Antineoplastic Agents (chemistry, isolation & purification, therapeutic use)
• Colorectal Neoplasms (drug therapy, pathology)
• Dipeptides (chemistry, isolation & purification, therapeutic use)
• Diterpenes (chemistry, isolation & purification, therapeutic use)
• Eurotiales (chemistry)
• Humans
• Inhibitory Concentration 50
• Lung Neoplasms (drug therapy, pathology)
• Penicillium (chemistry)
• Spectrum Analysis
• X-Ray Diffraction