The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C.

Chemical investigations of a culture broth from the endophytic fungus Eupenicillium sp. afforded the new modified dipeptide trichodermamide C 1. The structure of 1 was established following the analysis of NMR, UV, IR, MS and X-ray diffraction data. Trichodermamide C was shown by high content screening to display cytotoxicity towards the human colorectal carcinoma HCT116 and human lung carcinoma A549 with IC(50) values of 0.68 and 4.28microg/ml, respectively.
AuthorsRohan A Davis, James Longden, Vicky M Avery, Peter C Healy
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 9 Pg. 2836-9 (May 1 2008) ISSN: 1464-3405 [Electronic] England
PMID18424045 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Dipeptides
  • Diterpenes
  • trichodermamide C
  • Antineoplastic Agents (chemistry, isolation & purification, therapeutic use)
  • Colorectal Neoplasms (drug therapy, pathology)
  • Dipeptides (chemistry, isolation & purification, therapeutic use)
  • Diterpenes (chemistry, isolation & purification, therapeutic use)
  • Eurotiales (chemistry)
  • Humans
  • Inhibitory Concentration 50
  • Lung Neoplasms (drug therapy, pathology)
  • Penicillium (chemistry)
  • Spectrum Analysis
  • X-Ray Diffraction

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